QTP104 is a next-generation mRNA vaccine (repRNA: involved in self-amplification mRNA) encoding the
Spike(S) protein of SARS-CoV-2. repRNA is capable of inducing a strong immune response with a smaller
amount than simple mRNA vaccines by inserting replicase that is involved in self-amplifying. In addition, it
has the advantage that there is no PEG-related allergic side effect by using LION formulation that doesn’t
contain PEG components as a delivery material.
＊LIONs: Lipid Inorganic Nanoparticles
Mechanism of Action
RNA encoding spike protein delivered to immune cells through LNP technology (LION)
Like the simple mRNA vaccine, QTP104 induces the antigen, which leads to the formation of antibodies.
repRNA has the advantage of more antigenic production than simple mRNAs by replicase.